While I can’t so myself, I have friends that can and enjoy doing so. Yuki Mori a Ph.D student, at Fine Digital Engineering Laboratory Research Center for Advanced Science and Technology (RCAST) The University of Tokyo, has developed a system called Plushie that enables you to design and create patterns for 3D plush toys.

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Yuki Mori, Takeo Igarashi. Plushie: An Interactive Design System for Plush Toys. ACM Transactions on Graphics (Proceedings of SIGGRAPH 2007), vol.23, No.3, Article No.45, San Diego, USA, August 2007 (Link to the PDF is available on her site).